Search results for "Multi-type birth–death model"

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Quantifying transmission fitness costs of multi-drug resistant tuberculosis.

2021

As multi-drug resistant tuberculosis (MDR-TB) continues to spread, investigating the transmission potential of different drug-resistant strains becomes an ever more pressing topic in public health. While phylogenetic and transmission tree inferences provide valuable insight into possible transmission chains, phylodynamic inference combines evolutionary and epidemiological analyses to estimate the parameters of the underlying epidemiological processes, allowing us to describe the overall dynamics of disease spread in the population. In this study, we introduce an approach to Mycobacterium tuberculosis (M. tuberculosis) phylodynamic analysis employing an existing computationally efficient mod…

EpidemiologyComputer scienceAntibiotic resistance030231 tropical medicinePopulationAntitubercular AgentsInferenceInfectious and parasitic diseasesRC109-216Drug resistanceComputational biologyMicrobial Sensitivity TestsMicrobiologylaw.inventionMycobacterium tuberculosis03 medical and health sciencesMulti-type birth–death model0302 clinical medicinelawVirologyMulti-type birth-death modelTuberculosis Multidrug-ResistantmedicineHumans030212 general & internal medicineWhole genome M. tuberculosiseducationEpidemicsPhylogenyeducation.field_of_studybiologyPhylogenetic treeMulti-drug-resistant tuberculosisPublic Health Environmental and Occupational HealthAntibiotic resistance; Multi-type birth–death model; Phylodynamics; Whole genome M. tuberculosisMycobacterium tuberculosismedicine.diseasebiology.organism_classificationPhylodynamics614: Public Health und GesundheitsförderungInfectious DiseasesViral phylodynamicsTransmission (mechanics)ParasitologyEpidemics
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